our research
I am a Professor in the Department of Biochemistry at Western University. Trainees in my lab develop tools for gene editing and synthetic biology.
We use evolutionary, genetic, structural and biochemical approaches to design, test and optimize CRISPR-based nucleases for precise and efficient gene editing. We apply our tools to better enable genome editing in eukaryotic algae, control of microbial populations, and treatment of human disease.
Learn more about our research →
news
- Congrats to Dr. Tyler Browne on defending his PhD thesis!
- Congrats to Raagul Sivacumar on defending his MSc thesis!
- Congrats to Dr. Gary Foo on defending his PhD thesis!
- Congrats to Dr. Kurt Loedige for a successful PhD thesis defence!
- Congrats to Dr. Dalton Ham for successfully defending his PhD thesis!!
- Our paper on using algae to make the COVID-19 receptor binding domain for diagnostics was selected as one of the !! Top 100 papers in 2022 by Scientific Reports
latest publications
PHYCUT: Scalable Multiplex CRISPR/Cas9 editing for Genome Engineering in the Diatom Phaeodactylum tricornutum
Stuckless EE, Gai LS, Slattery SS, Dempsey KH, Browne TS, Gloor GB, Edgell DR
ACS Synthetic Biology (2026)
Better data for better predictions: data curation improves deep learning for sgRNA/Cas9 prediction
Browne TS, Edgell DR, Gloor GB
PeerJ (2026)
Machine learning reveals sequence and methylation determinants of SaCas9-PAM interactions in bacteria
Ham DT, Browne TS, Zhang CQ, Foo GW, Uruthirapathy AS, Gloor GB, Edgell DR
Nucleic Acids Research (2026)